NMN（nicotinamide mononucleotide）a substance naturally produced in the bodies of humans and living organisms,and is instrumental in producing the vital energy our cells need for all human activity.。Moreover, it is believed to slow down the effects of aging.
The frontlines of aging and longevity research.
In a yearlong effectiveness trial, NMN was administered to mice, with the outcomes indicating that, compared to ordinary mice, it helped reduce the effects of weight gain in middle age, curb decreased energy metabolism from age, curb decreased bone density, and curb decreased ocular function, among other types of organ degradation. In addition, it has been found to be beneficial against other ailments such as diabetes, Alzheimer's disease, heart failure, kidney failure, and more. In other words, these findings demonstrated the clear anti-aging effects of NMN.
Ailments in which sirtuins are implicated
Sirtuin family functionality and diseases
| Molecular name | Localization site | Function | Related diseases |
|---|---|---|---|
| SIRT 1 | Nuclei, cytoplasm | Nuclei, cytoplasm Glucose metabolism, fat oxidation, circadian rhythms, inflammatory diseases | Diabetes, dementia, lifespan |
| SIRT 2 | Nuclei, cytoplasm | Cell growth inhibition, DNA damage, inflammatory diseases | Cancer, inflammatory diseases, heart disease, lifespan |
| SIRT 3 | Mitochondria | Energy (ATP) synthesis, citric acid circuit, electron transport chain, oxidative phosphorylation, amino acid metabolism, lipid metabolism, protein metabolism, reactive oxygen species (ROS), mitochondrial quality control | Heart disease, neurodegenerative disease, acute nephritis, cancer |
| SIRT 4 | Mitochondria | Amino acid metabolism, lipid metabolism, citric acid circuit | Cancer, obesity |
| SIRT 5 | Mitochondria | Lipid metabolism, glycolysis, free radicals, urea cycle | Cancer, heart disease |
| SIRT 6 | Nuclei | Genome stability, telomere and centromere control, DNA repair, glucose metabolism, lipid metabolism | Cancer, inflammatory diseases, heart disease, lifespan |
| SIRT 7 | Nuclei | Ribosome biosynthesis, cell stress response | Metabolic disease, cancer, lifespan |
