NMN is found in breast milk and vegetables with high beta-carotene, such as broccoli, avocadoes, and green soybeans. However, the quantity found in these foods is extremely minimal. NMN is converted into NAD in the body, but this gradually decreases with age. In our late 50s, its quantity is nearly half of what it once was, and continues to decline thereafter. As a result, it becomes impossible to supplement it with food alone. Therefore, consuming NMN like a supplement is a means of curbing the onset of aging.
NMN content in food
| Food | NMN content mg/kg-food | Food weight (kg/250mg) *-NMN | How much should you consume to obtain 250mg* equivalent of NMN? | Reference |
|---|---|---|---|---|
| Edamame (green soybeans) | 5 – 19 | 14 – 54 | 20,000 pieces | 3g/bean Bean: pod = 1:1 weight |
| Broccoli | 3 – 11 | 22 – 100 | 4,000 pieces | 350g/bunch 25g/piece |
| Cucumber (seed) | 6 | 44 | – | 140g /cucumber |
| Cucumber (skin) | 7 | 38 | – | 140g /cucumber |
| Cabbage | 0 – 9 | 0 – 28 | 28 pieces | 1kg/piece |
| Avocado | 4 – 16 | 16 – 70 | 600 tomatoes | 170g/piece 120g (edible portion)/piece |
| Tomatoes | 3 | 84 – 96 | 600 tomatoes | 150g/piece |
| Mushrooms | 0 – 10 | 0 – 24 | 2,000 mushrooms | 12g/piece |
| Beef (raw) | 1 – 4 | 60 – 416 | 2,000 steaks | 150g/steak |
| Shrimp | 2 | 114 | 10,000 shrimp | 10g/piece |
*Amount currently consumed by humans in clinical studies of NMN
Cell Metab. 2016 Dec 13;24(6):795-806.
NMN content in raw milk
| Type | NMN content (μM) in milk | NMN content (mg/L-milk) | How much should you consume (in liters) to obtain 250mg* equivalent of NMN? | Reference |
|---|---|---|---|---|
| Human milk | 6.1 | 2.0 | 122 | – |
| Cow milk | 0.9 | 0.3 | 832 | (not contained in commercially available milk) |
| Buffalo milk | 0.0 | 0.0 | – | – |
| Sheep milk | 0.3 | 0.1 | 2,494 | – |
| Goat milk | 2.1 | 2.1 | 356 | – |
| Donkey milk | 0.4 | 0.1 | 1,870 | – |
*Amount currently consumed by humans in clinical studies of NMN
Food Chem.2017 Apr 15;221:161-168
The Role of NMN in Anti-aging
There are mechanisms to suppressing aging and the role of NMN. Here we describe NAD, mitochondria, and sirtuin in order to help you better understand the mechanisms behind suppression of aging and the role played by NMN.
会随着年龄的增长而减少。
[ NMN ]
When consuming NMN through the mouth, it passes through NMN transporters present on the cell surface and is absorbed into cells, where it is converted into NAD.
最后转换为NAD。
[ NAD ]
NAD (nicotinamide adenine dinucleotide) can be found in the cells of every living organism,
and is the source of the body's internal metabolism, being used whenever energy is produced.
However, NAD production begins to decrease in the body as we age.
Moreover, research has found that when consumed directly, NAD tends not to reach the cells,
so consuming NMN, a NAD precursor, is a more efficient means of delivering it to the body.
Attention is being drawn to NAD for its potential use in anti-aging using the two methods below.
Synthesis of energy (ATP) in the mitochondria
ATP refers to a source of energy that all living things use to survive. All eukaryotic cells and most archaebacteria and bacteria use NAD to synthesize ATP. NAD is essential to the synthesis of ATP; without it, living organisms die.
Sirtuin (SIRT) activation
The mechanisms behind aging hinge on an enzyme called sirtuin. This may be an unfamiliar term, but it is a protein that exists widely in organisms from bacteria to mammals, and plays a special role in controlling aging and lifespan. Humans possess a class of seven proteins called sirtuins that help control aging of the organs, but these sirtuins are normally dormant. NAD functions as a switch that acts on all seven of these sirtuins. In other words, as NAD declines through aging, the "switch" controlling sirtuins stops functioning, which is believed to contribute to decreased organ and tissue function.
通过增加NAD，活化乙酰化酶，抑制衰老。
Effective Anti-aging Can Be Expected
NMN + Wasabi sulphorafane（6-MSITC）
Wasabi sulforaphane protects cells, and consuming it in conjunction with NMN aids in activating cells while preventing inflammation and oxidation, helping cells remain more youthful. For those with weakened cells as a result of aging, the combined use of NMN, which helps in activating cells from the inside out, and wasabi sulphorafane, which protects cells from external stressors, is recommended.
*Note that the image is a conceptual rendering. It is not intended to reflect actual effects in the human body.What is 6-MSITC?The word stands for 6-Methylsulfinylhexyl Isothiocyanate. It is a nutritional component contained at a small quantity in the rhizome of wasabi after removing wasabi’s unique pungent components. It has the effect of improving some cognitive functions like decision-making abilities (abilities for processing information accurately), improves attentiveness, and limits the production of active enzymes with its powerful antibacterial properties.
